PL Thomas has released the results of a new study using its dietary supplement ingredient, GliSODin, which were recently presented at the 11th Congress of the European Shock Society in Vienna, Austria. The study was conducted by a team of researchers at the University of Ulm, Germany, and it looked at ischemia-reperfusion injury, which can be a concern during surgery, caused by the restriction and reintroduction of blood flow. The generation of oxygen-derived radicals has been demonstrated to be the major mechanism of ischemia-reperfusion induced oxidative damage. In this animal study, swine were given GliSODin or placebo, and DNA damage was evaluated in blood samples before and after hyperbaric-oxygen induced oxidative stress, using a measure of DNA strand breaks. The GliSODin group demonstrated significant DNA protection compared to placebo. DNA strand breaks were then used to evaluate DNA damage induced by ischemia-reperfusion. During thoracic aortic surgery, whole blood samples were taken before thoracic aortic cross-clamping, 30 minutes after clamping, and two and four hours after declamping. GliSODin reduced oxidative DNA damage related to surgical stress and ischemia-reperfusion after aortic clamping compared to placebo, resulting in a statistically significant difference two hours after declamping. Finally, isoprostane levels, another marker of oxidative stress, increased in both hepatic venous and portal venous samples of the placebo group, but not in the GliSODin group.